ANTIBIOTICS PRODUCED BY MUTANTS OF STREPTOMYCES CAELESTIS. I

Antibiotics produced by Streptomyces.

Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a chain of spores. The most interesting property of Streptomyces is the ability to produce bioactive secondary metabolites, such as antifungals, a...

New macrolide antibiotics produced by mutants from Streptomyces fradiae NRRL 2702.

A35512, a complex of new antibacterial antibiotics produced by Streptomyces candidus. I. Isolation and characterization.

The new antibiotic complex A35512 produced by Streptomyces candidus was isolated from the filtered fermentation broth. The individual factors A, B, C, E, and H were separated and purified by column chromatography. A35512B, the major factor, was isolated as the dihydrochloride salt, a white crystalline compound with an approximate empirical formula of C90H101 N8O39Cl.2HCl. The A35512 antibiotics...

Kitamycins, new antimycin antibiotics produced by Streptomyces sp.

In the course of our screening program for plant growth inhibitors, Streptomyces sp. K385 isolated from a soil sample collected in OkayamaJapan, was found to produce kitamycin A (1) and B (2), new antimycin type antibiotics, together with known antimycin type antibiotics, antimycin A1? A2a, A3, A4a1?2), urauchimycin B (3)3), and deisovalerylblastmycin (4).4?5) This study describes the fermentat...

Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are ...